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        • USP 4 Header

        Innovative features

        For improved Flow-Through Testing.

        Standardized cell head

        The new cell head fits all offered cell bodies and thus enables a faster assembly of cells while offering lower purchasing costs (needed only 1x per system). Faster tube mounting is also possible through a quick lock in the cell head.

        Increased leak-tightness

        Due to reducing the number of seals to 3 pieces per cell and using flat seals with an increased sealing surface, the process safety can be heightened.

        Optimized cell bodies & individual cell heating

        The reduction of the cell body provides a better heating and faster preparation of cells. Each cell can be heated individually via a rotary switch.

        Compact & corrosion-resistant housing

        The smaller footprint with clear arrangement of cells in one line saves laboratory space and offers a perfect visual control of the cells at all times. In addition, the tube organizer on the back of the device prevents mixing up the cell tubes.

        Easier cleaning

        Due to the 3-way-valve for water emptying on the back of the device, the water bath can be cleaned much easier. In addition, simple water control is possible with the water level pointer (colour coding) and the two openings for PT 100 sensors on the device cover.
        • Standardized cell head

          The new cell head fits all offered cell bodies and thus enables a faster assembly of cells while offering lower purchasing costs (needed only 1x per system). Faster tube mounting is also possible through a quick lock in the cell head.
        • Increased leak-tightness

          Due to reducing the number of seals to 3 pieces per cell and using flat seals with an increased sealing surface, the process safety can be heightened.
        • Optimized cell bodies & individual cell heating

          The reduction of the cell body provides a better heating and faster preparation of cells. Each cell can be heated individually via a rotary switch.
        • Compact & corrosion-resistant housing

          The smaller footprint with clear arrangement of cells in one line saves laboratory space and offers a perfect visual control of the cells at all times. In addition, the tube organizer on the back of the device prevents mixing up the cell tubes.
        • Easier cleaning

          Due to the 3-way-valve for water emptying on the back of the device, the water bath can be cleaned much easier. In addition, simple water control is possible with the water level pointer (colour coding) and the two openings for PT 100 sensors on the device cover.


          Highlights

          The highlights of the new

          USP 4 Flow-Through Cell DFZ II

          The new ERWEKA flow-through cell tester DFZ II can be used for various applications thanks to its wide range of available cell types, e.g. for testing poorly soluble products or low-dose formulations with sustained release.

          Innovations as the new cell design with increased leak-tightness and the optimized tubing system with quick locks allow a fast preparation and implementation of dissolution tests. The new leaner cell bodies ensure an improved cell warming and can be heated individually. All USP 4 DFZ II systems can be easily controlled with the Disso.NET USP 4 dissolution software via a controller.


          Zellendesign

          New improved

          Cell design

          Accompanying our flow-through systems, we offer a variety of different cells with a new improved design for different purposes - from the standard tablet cell to granulate & powder cells to cells for implants, suppositories and stents.

          The new standardized cell head fits all offered cell bodies and facilitates along with the new standardized flat seals (only 3 pieces per cell: connection, head and heating jacket) handling and assembly of the cells. The optimized cell bodies with decreased cell wall thickness guarantee an improved cell heating.

          Thanks to this new cell concept, the cells can be mounted easier to the new flow-through tester DFZ II and thus enable a faster preparation and performance of dissolution tests.


          Different USP 4 cells available

          Different cells for different purposes available - e. g. for implants, granulates & powders, suppositories, stants, cells with creme adapter or with a dialysis adapter.

          • Tablet cell 12,00 mm

          • Tablet cell 22,6 mm

          • Granulate & Powder cell

          • Implant cell

          • Suppository cell

          • Stent cell

          • Tablet cell 22.6 mm with dialysis adapter

          • Tablet cell 22.6 mm with cream adapter

          • Tablet cell 22.6 mm with glass beads

          • Tablet cell 22.6 mm with glass beads


          Disso.NET USP 4

          Disso.NET USP 4

          Full dissolution software solution for the Flow-Through Cell

          The ERWEKA Disso.NET USP 4 Software is the perfect companion for our USP 4 systems. The software takes over full control of our USP 4 systems and offers support of all USP/EP dissolution cells used in these systems. It also supports cells for special applications (e.g. cell with cream adapter) and visual guides for formulation placing in the respective cells.

          The software includes an easy to handle method editor for comfortable programming of dissolution methods (for highest safety in GMP environment). Our audit trail also generates detailed protocols of all events and times and thus enables tracing changes at any time. After finishing the dissolution test, Disso.NET USP 4 creates comprehensive reports (as PDF-files) and can export all results in various formats (e.g. as XML-file).


          USP 4 Systems

          Adapted individually to your needs.

          • USP 4 Stand-Alone System

            USP 4 Stand-Alone System

            Easy entry into USP 4 dissolution testing

            The ERWEKA stand-alone flow-through cell system is perfect for performing simple release tests with manual sampling. Therefore, the new flow-through cell tester DFZ II offers in a system with the ERWEKA piston pump HKP 720 and the ERWEKA heater DH 2000i an easy entry into testing with USP 4 systems for a small budget.

            The stand-alone system consists of:

            • Piston pump HKP 720
            • Flow-through cell DFZ II + heater DH 2000i
          • USP 4 Open Offline System

            USP 4 Open Offline System

            Infinite media testing and sampling

            The open ERWEKA offline flow-through cell system is the perfect solution for testing poorly soluble products that need unlimited amounts of fresh media to dissolve.

            With the ERWEKA sample collector FRL 724 representative samples are taken over a certain period for later analysis (up to 18 sampling intervals possible).

            The system configuration comprises:

            • Piston pump HKP 720
            • Flow-through cell DFZ II + heater DH 2000i
            • Sample collector FRL 724
            • Controller with Disso.NET USP 4 software
            • One or more medium reservoirs
          • USP 4 Closed Offline System

            USP 4 Closed Offline System

            Comprehensive long-term testing

            The closed ERWEKA offline flow-through cell system is excellently suited for testing low-dose formulations with sustained release (e.g. implants). It allows performing comprehensive long-term dissolution tests with small media volumes.

            The system configuration consists of:

            • Piston pump HKP 720
            • Peristaltic pump IPC 8
            • Flow-through cell DFZ II + heater DH 2000i
            • Media transfer station LMT 2
            • Sample collector FRL 724
            • Controller with Disso.NET USP 4 software
          • USP 4 Closed Online System

            USP 4 Closed Online System

            Comprehensive long-term testing with integrated analytic

            The USP 4 Closed Online System is our solution with automated analytic for the USP 4 flow-through cell. The software controlled USP 4 system integrates USP 4 flow-through cell testing with directly connected analytic UV/Vis online measurement, resulting in an automated USP 4 workflow.

            Furthermore, all features of the stand-alone system can be applied to our online system: the valve-free piston pump with highest precision and the low-vibration heater steadily holds the requested temperature of the waterbath. And our new and improved DFZ II USP 4 cells are also integrated into the software dialogs, making the use of the system as easy as possible.



          LMT 2

          LMT 2

          Easy media transfer

          With the compact ERWEKA media transfer station LMT 2 a closed loop for performing long-term dissolution tests according to USP 4 can be easily created. The LMT 2 is therefore used as a medium reservoir and ensures an optimal media mixing and distribution through the whole release test.

          The optimized tubing system with a new tube holder and rotatable bottle caps (safety caps) makes handling easier and saves valuable laboratory space.


          Gallery

          Get an impression of the ERWEKA USP 4 DFZ ll Flow-Through Cell System.


          Download

          Our Brochure.

          USP 4 DFZ ll Brochure

          USP 4 DFZ ll Brochure

          Download our brochure for more in-depth information.

          Download

           

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